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DIN (Drug Identification Number)
02450291 LENVIMA 24 MG Dose
02450305 LENVIMA 20 MG Dose
02450313 LENVIMA 14 MG Dose
02450321 LENVIMA 10 MG Dose
How does this medication work? What will it do for me?
Lenvatinib belongs to the group of cancer-fighting medications called antineoplastics, and specifically to the family of medications called protein kinase inhibitors. It is used to treat thyroid cancer that has recurred or metastasized (spread) or progressed despite radioactive-iodine treatment.
Lenvatinib works by recognizing and attaching to certain types of cancer cells. This may slow down or stop cancers from growing and dividing.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
The recommended adult dose of lenvatinib is 24 mg taken by mouth once daily (2 × 10 mg capsules and 1 × 4 mg capsule per dose), at the same time every day. Your doctor may adjust the dose based on side effects that you experience, until a balance between side effects and effectiveness is reached.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Swallow the capsules whole, with water. Do not crush or chew the medication. Lenvatinib may be taken with food or on an empty stomach.
It is important to take this medication exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is more than 12 hours since the missed dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
How should I use this medication?
Each hard hypromellose capsule with a yellowish-red body and yellowish-red cap, marked in black ink with “Є” on the cap and “LENV 4 mg” on the body, contains lenvatinib mesylate equivalent to 4 mg of lenvatinib. Nonmedicinal ingredients: calcium carbonate, mannitol, microcrystalline cellulose, hydroxypropylcellulose, low-substituted hydroxypropylcellulose, and talc; capsule shell: hypromellose, titanium dioxide (E171), yellow iron oxide (E172), and red iron oxide (E172); printing ink: shellac, black iron oxide (E172), potassium hydroxide, and propylene glycol.
Each hard hypromellose capsule with a yellow body and yellowish-red cap, marked in black ink with “Є” on the cap and “LENV 10 mg” on the body, contains lenvatinib mesylate equivalent to 10 mg lenvatinib. Nonmedicinal ingredients: calcium carbonate, mannitol, microcrystalline cellulose, hydroxypropylcellulose, low-substituted hydroxypropylcellulose, and talc; capsule shell: hypromellose, titanium dioxide (E171), yellow iron oxide (E172), and red iron oxide (E172); printing ink: shellac, black iron oxide (E172), potassium hydroxide, and propylene glycol.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take this medication if you are allergic to lenvatinib or any ingredients of the medication.
What side effects are possible with this medication?
- abdominal pain
- decreased appetite
- weight loss
- rash, redness or itching of the palms of the hands or soles of the feet
- signs of blood clots (e.g., coughing up blood; pains in chest, groin, or leg – especially in calf of leg)
- signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
- signs of heart failure (e.g., shortness of breath, fatigue, swelling in legs, ankles, feet)
- signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of a tear in the stomach or intestinal wall (e.g., severe abdominal pain, nausea, vomiting, chills, fever)
- signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
- signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
- signs of posterior reversible encephalopathy syndrome (e.g., headache, seizures, weakness, confusion, high blood pressure, vision changes, difficulty thinking clearly)
- very high blood pressure (e.g., headache, vision changes, nausea and vomiting)
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Are there any other precautions or warnings for this medication?
- are female
- are older than 65 years of age
- have a family history of sudden death due to heart attack or similar heart problems
- have a history of heart disease or abnormal heart rhythms
- have a slow heart rate
- have congenital prolongation of the QT interval
- have diabetes
- have had a stroke
- have low potassium, magnesium, or calcium levels
- have nutritional deficiencies
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Abnormal heart rhythms: This medication can cause abnormal heart rhythms. Certain medications (e.g., sotalol, quinidine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation and should not be used in combination with lenvatinib. You are more at risk for this type of abnormal heart rhythm and its complications if you:
If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., verapamil, atazanavir), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Birth control: Effective birth control should be practiced while using this medication. Males taking this medication should use a spermicide in addition to a barrier method of birth control (e.g., condoms). Women taking this medication must also use reliable birth control while taking lenvatinib and for at least 1 month after stopping the medication. The effectiveness of hormonal contraceptives, such as birth control pills has not been determined. Barrier methods of birth control are recommended.
Bleeding: Lenvatinib may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Blood clots: This medication may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.
If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, or stroke. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. The safety of using this medication within 6 months of experiencing a blood clot has not been studied.
Gastrointestinal problems: Lenvatinib can cause perforation of the stomach or intestines. If you experience severe abdominal pain, fever, vomiting, or nausea, contact your doctor immediately.
Heart function: This medication may cause symptoms of heart failure. Contact your doctor as soon as possible if you develop symptoms of heart problems such as shortness of breath, chest pain, rapid heartbeat, or swollen ankles.
High blood pressure: Lenvatinib can cause increased blood pressure. If you have high blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney function/failure: This medication can cause decreased kidney function or kidney failure. If you experience puffy hands, face, or feet, high blood pressure, unusual muscle cramping, or darkened urine, this medication may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your doctor as soon as possible.
Liver function: This medication is broken down by the liver. Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
Lenvatinib has been reported to cause a decrease in liver function, which has in rare cases caused liver failure. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Reversible posterior leukoencephalopathy syndrome (RPLS): This is a rare disease of the brain that may occur when using medications like lenvatinib. If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness or vision changes, contact your doctor immediately.
Surgery: This medication causes changes to the blood and any slow down the healing process for wounds. Make sure anyone involved in your medical care knows you are taking lenvatinib.
Thyroid function: This medication can affect the way the body uses thyroid hormones. If you take thyroid replacement medication, your doctor may need to adjust the dose while you are taking lenvatinib.
Pregnancy: Lenvatinib is likely to harm the developing baby if it is taken by the mother while she is pregnant. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if lenvatinib passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Seniors: People over the age of 65 years may be more at risk of side effects from this medication.
What other drugs could interact with this medication?
- antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- chloral hydrate
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
- selective serotonin reuptake inhibitors (ssris; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
- certain other tyrosine kinase inhibitors (e.g., bosutinib, dasatinib, nilotinib, sunitinib)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
There may be an interaction between lenvatinib and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Lenvima
All material © 1996-2019 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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